On May 15, 2012, the Official Journal of the European Union promulgated Regulation (EU) No 412/2012, officially adding dimethyl fumarate DMF to Appendix 17 of the REACH Regulation (concerning hazardous substances, Mixtures and finished products, their manufacture and placement on the market are restricted) Item 61 of the list of substances. This regulation takes effect 20 days after publication in the European Journal and requires member states to unconditionally transfer it to their national laws. Prior to this, the EU issued revised regulations 2012/48/EU on the DMF ban on January 26, 2012, extending the effective date of the dimethyl fumarate ban (2009/251/EC) to March 15, 2013. . However, Regulation 2012/48/EU clearly states that if the proposal to list dimethyl fumarate in Appendix 17 of the REACH regulation for mandatory control is formally adopted earlier than the former, the ban on dimethyl fumarate will take effect immediately. That is to say, the 2012/48/EU directive "Extension of the Effective Date of Dimethyl Fumarate" issued by the EU will be invalidated at the same time as the effective date of (EU) No 412/2012, that is, starting from June 4, the entire EU will restrict Dimethyl fumarate is used. Substance name CAS number EC number restriction conditions 61. Dimethyl fumarate (DMF) 624-49-7 210-849-0 (1) The content of DMF used in articles and any component of articles shall not be
