European Commission Releases Guidelines for the Assessment of Mixtures The European Commission’s Joint Research Center (JRC) recently released a comprehensive guide on methodologies for assessing the toxic effects of mixtures, providing manufacturers with more complete information on mixture testing. In addition to comprehensively summarizing the toxic effects methodologies of many mixtures recognized by the EU, this report also contains an incisive summary of the harmful substances content of the EU's hazardous substances-related regulations and directives, providing manufacturers with information on hazardous substances that can integrate all regulations and directives. Require. The regulations and directives summarized in the guide are as follows: – Plant protection products regulations (Reg 1107/2009); – Public-private partnership regulations - active ingredient requirements (PPP-